Dietary protein restriction

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Dietary Protein Restriction in the Management of Chronic Kidney Disease

The number of patients with chronic kidney disease (CKD) – especially with diabetic nephropathy – is expected to grow significantly in the future.1,2 CKD is associated with substantial morbidity and mortality, and the consequence of this emerging public health problem is considerable consumption of medical and financial resources. This epidemic has led to the development of therapeutic and mana...

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Effect of dietary protein restriction on liver transcription factors.

The transcription of several genes that are preferentially expressed in the liver, including the serum albumin, transthyretin and carbamyl phosphate synthetase-I genes, is specifically decreased in animals consuming inadequate amounts of dietary protein. The high level of transcription of these genes in the liver is directed in part by a number of liver-enriched transcription factors, including...

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Effect of dietary protein restriction on renal ammonia metabolism.

Dietary protein restriction has multiple benefits in kidney disease. Because protein intake is a major determinant of endogenous acid production, it is important that net acid excretion change in parallel during protein restriction. Ammonia is the primary component of net acid excretion, and inappropriate ammonia excretion can lead to negative nitrogen balance. Accordingly, we examined ammonia ...

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A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction

During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-term preoperative 30% dietary restriction (DR) and 3-day fasting protect against renal IRI. We investigated the contribution of macronutrients to this protection on both phenotypical and transcriptional levels. Male C57BL/6 mice were fed control food ad libitum, underwent two weeks of 30%DR, 3-day f...

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Dietary restriction with and without caloric restriction for healthy aging

Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20-40% reduction of food consumption relative to normal intake, is a severe intervention that re...

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ژورنال

عنوان ژورنال: Nephrology

سال: 2006

ISSN: 1320-5358,1440-1797

DOI: 10.1111/j.1440-1797.2006.00601.x